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. 2012 Feb 15;2012:219319. doi: 10.1155/2012/219319

Figure 1.

Figure 1

Effect of 5 mg/kg rosiglitazone (RGZ) on parameters of renal function in Sprague-Dawley rats in renal I/R injury. After either a sham operation or a bilateral clamping of the renal arteries for 60 min, rosiglitazone was applied i.p. or not, and parameters of renal function were determined 24 h afterwards. Parameters were additionally determined in untreated control rats. n as indicated. #Statistically significant difference as indicated. (a) Renal clearance of inulin was determined as a measure of GFR as described in Section 2 (GFR = (I U × V U)/(I P × t), where IU is inulin concentration in urine, IP is inulin concentration in plasma, VU is urine volume, t is time of measurement, and GFR is glomerular filtration rate). (b) Renal clearance of PAH was determined as described in Section 2 (PAH clearance = (PAHU × V U)/(PAHP × t), where PAHU is PAH concentration in urine, PAHP is PAH concentration in plasma). (c) Renal net secretion of PAH (PNS) was determined as described in Section 2  {PNS = [(PAHU × V U)/t]−[GFR × PAHP]}.