Fig. 1.

Representative transmission electron microscopy micrographs show mitochondrial biogenesis (long arrows), and mild cardiac steatosis (arrowheads), indicative of myocyte disarray, in 9-wk-old Zucker obese (ZO) compared with Zucker lean (ZL) rats. ZO hearts have elevated levels of 3 nitrotyrosine immunostaining indicative of oxidative stress (B) and increased interstitial fibrosis (C). MRI images (D) and bar graph (E) indicate prolonged relaxation time, demonstrating diastolic impairment. *P < 0.05 Bars represent means ± SE; n = 6 for both groups. Figure is reprinted with permission: Zhou X, Ma L, Habibi J, Whaley-Connell A, Hayden MR, Tilmon RD, Brown AN, Kim JA, Demarco VG, Sowers JR. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat. Hypertension 55: 880–888, 2010.