Table 1. Demographic characteristics and underlying conditions in 8 patients with H275Y mutation of pandemic (H1N1) 2009 virus, Seattle Cancer Care Alliance, Seattle, Washington, USA, May 1, 2009–April 30, 2010*.
| Patient no. | Age, y/sex | BMI | Underlying disease | State of disease | HCT | Recent immunosuppressive therapy | Concurrent illness | Lymphocytes, × 103 cells/L |
|---|---|---|---|---|---|---|---|---|
| 1† |
51/M |
20.5 |
AML |
Remission |
2 y
post–allo-HCT |
MMF, tacrolimus |
GVHD, renal failure |
110 |
| 2† |
47/F |
22.9 |
AML |
Relapse |
3 y
post–allo-HCT |
Chemotherapy 1 mo before
influenza dx and 1 d after-dx |
None |
540 |
| 3 |
50/M |
23.3 |
CML |
Remission |
9 mo
post–allo-HCT |
TBI,
cyclophosphamide,
tacrolimus |
GVHD |
1,470 |
| 4 |
7/F |
18.9 |
ALL |
Relapse |
NA |
Chemotherapy 2 d after influenza
diagnosis; prednisone 1.5 mg/kg/d |
None |
1,440 |
| 5 |
34/F |
38.8 |
Hogkin lymphoma |
Refractory |
2 d
pre–allo-HCT |
TBI, fludarabine,
cyclophosphamide |
Renal failure |
0 |
| 6† |
17/M |
19.5 |
ALL (T cell) |
Remission |
3 wk
post–allo-HCT |
TBI, fludarabine,
cyclophosphamide,
MMF, CSA, prednisone 0.5
mg/kg/d |
CMV, GVHD |
154 |
| 7 |
17/M |
22.4 |
Osteosarcoma |
Relapse |
NA |
Chemotherapy 1 d before
influenza diagnosis |
Lung metastasis, thoracotomy,
restrictive syndrome |
366 |
| 8 | 8/F | 14.5 | Aplastic anemia | Treatment | NA | ATG, CSA maintenance | None | 1,145 |
*BMI, body mass index; HCT, hemopoietic cell transplant; AML, acute myeloblastic leukemia; allo, allogenic; MMF, mycophenolate mofetil; GVHD, graft-versus-host disease; NA, not applicable; CML, chronic myeloblastic leukemia; TBI, total body irradiation; ALL, acute lymphoblastic leukemia; CSA, cyclosporine; CMV, cytomegalovirus; ATG, antithymocyte globuline. †Patients previously reported in references (5,13).