Table 5.

Relationship between Time Dependent Changes in Clinical Status and Risk of Cardiovascular Hospitalizations

		Amio versus Rate		Sotalol versus Rate		Class 1C versus Rate
		HR and 95% CI	p-value	HR and 95% CI	p-value	HR and 95% CI	p-value
SR to AF NYHA Class		1.87(1.40, 2.50)	<.0001	1.76(1.29, 2.41)	<.001	1.11(0.64, 1.94)	0.7139
	I	1.82(1.45, 2.29)	<.0001	1.35(1.00, 1.82)	<.0001	2.17(1.30, 3.63)	<.0001
	II	2.28(1.78, 2.93)		1.81(1.19, 2.77)		1.95(1.00, 3.82)
	III	3.51(2.42, 5.09)		3.72(2.19, 6.33)		4.23(1.49, 12.04)
	IV	7.44(3.42, 16.20)		15.61(4.65, 52.47)		22.45(6.01, 83.82)
Increase in NYHA class CHC Class		1.72(1.35, 2.20)	<.0001	1.98(1.39, 2.83)	<.001	1.25(0.67, 2.34)	0.4772
	I	2.20(1.68, 2.89)	<.0001	1.26(0.82, 1.92)	0.4877	2.58(1.28, 5.19)	<.001
	II	3.57(2.40, 5.30)		1.62(0.87, 3.01)		5.42(2.09, 14.01)
	III	3.73(1.61, 8.64)		2.20(0.64, 7.48)		6.37(1.19, 34.01)
	IV	4.08(1.29, 12.88)		1.96(0.45, 8.61)		28.74(3.10, 266.46)
Increase in CHC Class		1.25(0.87, 1.80)	0.2218	2.35(1.40, 3.92)	<.01	0.90(0.36, 2.22)	0.8144
VR		1.13(1.04, 1.24)	0.0067	1.10(1.00, 1.21)	0.0518	0.99(0.84, 1.16)	0.8984
Increase in VR by ≥ 15 bmp		1.25(0.96, 1.64)	0.1017	1.58(1.20, 2.07)	<.01	1.62(1.04, 2.51)	0.0328

Abbreviations: SR – sinus rhythm; AF – atrial fibrillation; VR – ventricular rate; NYHA – New York Heart Association heart failure class; CHC – Canadian Heart Association Classification for angina pectoris. Hazard ratio for VR is the increase in risk associated with a 15 bpm increase in VR