Plasma glucose, insulin, and lipoprotein profiles. A, B) Plasma glucose (A) and insulin levels (B) were measured in 3-mo-old mice fed chow ad libitum. C) Lipoprotein profiles were measured in mice after 16 h without food. IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; HDL, high-density lipoprotein. Solid squares, OB/OB; solid circles, ob/ob; open squares, Acox1−/−; open circles, Acox1−/−/ob/ob. ⋀P < 0.05 vs. OB/OB; *P < 0.05 vs. ob/ob; #P < 0.05 vs. Acox1−/−.