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Secondary structure motifs in proposed homologous protein domains. (a) Structure of the aromatic-residue-rich caveolin binding sequence as originally identified in Gα proteins,13 featuring a β-hairpin structure. (b, c) β-Strand-rich structures found among four putative CRAC motifs59 in the PDC-109 crystal structure.61 See Figure S5 for the complete protein context and additional details.
