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. Author manuscript; available in PMC: 2012 Feb 29.
Published in final edited form as: Cell. 2006 Sep 8;126(5):995–1004. doi: 10.1016/j.cell.2006.07.025

Figure 1. A General Method to Conditionally Control Protein Stability.

Figure 1

(A) Genetic fusion of a destabilizing domain (DD) to a protein of interest (POI) results in degradation of the entire fusion. Addition of a ligand for the destabilizing domain protects the fusion from degradation.

(B) Synthetic ligands for FKBP12 F36V.