Fig. 1.
Beneficial effects of sEHIs (AEPU and t-AUCB) in a mouse MI model. a, Structure of the two sEHIs used in our studies: 1-adamantan-1-yl-3-{5-[2-(2-ethoxy-ethoxy)-ethoxy]-pentyl}-urea (AEPU, 100 mg/L)[5] and trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB). b, Examples of whole hearts from MI mice treated with AEPU or t-AUCB compared to MI alone or sham-operated hearts. The mice were sacrificed after three weeks of follow up. Scale, 1 cm. c, Summary data for heart/tibial length ratios (mg/mm) from MI mice compared to untreated MI mice. Error bars are ± s.e.m. (n = 12). *p<0.05. Similar results were obtained with AEPU.
