Fig. 4. Prevention of cardiac arrhythmia inducibility and electrical remodeling in MI mice by sEH inhibitors.

a, In-vivo EPS in sham and treated compared to untreated MI animals. Sham and treated MI animals are shown in the upper panels. Lower panels are from untreated MI animals showing evidence of inducible atrial fibrillation (lower left panel) and ventricular tachycardia (lower right panel). Upper four tracing are surface ECG (Lead I, II and aVF). Lower two tracings are intracardiac electrogram showing atrial, and ventricular electrograms. Summary data are presented in Supplemental Table 1. b, Examples of AP recordings from LV free wall myocytes isolated from sham animals compared to treated and untreated MI animals at three weeks of follow up. APs recorded from MI mice were significantly prolonged compared to sham animals. Treatment with t-AUCB resulted in the normalization of the AP prolongation. Summary data for APD at 50 and 90% repolarization (APD₅₀ and APD₉₀ in ms) are shown in Panel c. (*p<0.05 comparing sham and treated MI animals to MI alone, n=12-15 cells for each group). d, Examples of Ca²⁺-independent outward K⁺ current traces elicited from a holding potential of −80 mV using test potentials of 2.5 seconds in duration from −60 to +60 mV in 10-mV increments. e, Summary data for the density of the peak outward components (*p<0.05 comparing sham and treated MI animals to MI alone). n=11-13 cells for each group.