Table 3. Results of brucellosis therapy in large patient series.

Author (year) [ref]	country	Years of study	N° cases	Therapeutic regimens	relapses	Failures	mortality	Hospital admission
Barroso Garcia P (2002) [56]	Spain	1972–1998	1595	TETR+STP ; TETR+STP+ Sulphonamide ; DX+STP ; STP+Sulphonamide+DX ; TETR	NR	NR	NR	No
Andropoulos (2007) [59]	Greece	1990–2003	144	DX+STP (>14 años); RF+TMP/SMX (niños)	4 (3%)	NR	0	Yes
Bosilkovski (2007) [57]	Macedonia	1998–2004	418	DX+RF+TMP/SMX ; DX+RF ; DX+RF+G	16.2%	10.4%	1	Yes (until improvement)
Aygen (2002) [55]	Turkey	1989–1998	480	DX+RF; DX+STP; TETR+STP; CPX	26 (5.4%)	0	3	NR
Memish (2000) [58]	Saudi Arabia	1983–1995	160	TETR+STP; DX+RF; TETR+STP+ RF; RF+TMP/SMX; RF+STP+TMP/SMX	7	NR	0	Yes
Buzgan (2010) [65]	Turkey	1998–2007	1028	DX+RF (most used); DX+STP; DX+RF+STP; DX+CPX; RF+TMP/SMX; RF+CPX	4.7%	NR	NR	Yes (2–3 weeks)
Al Shaalan (2002) [60]	Saudi Arabia	1984–1995	115 (children)	RF+TMP/SMX+STP; STP+TMP/SMX; RF+TMP/SMX; STP+TETR+TMP/SMXl; RF+DX+STP	8	NR	1	Yes
Savas l (2007) [61]	Turkey	2000–2002	140	DX+RF; DX+STP; RF+CPX; DX+RF+STP; RF+TMP/SMX	5	NR	0	Yes(37 patients)
Demirturk (2008) [62]	Turkey	2002–2006	99	DX+RF; DX+RF+CPX	0 (of 30 cases with follow up)	0	1	Yes

TETR = tetracycline, STP = streptomycin, DX = doxycycline, RF = rifampicin, TMP/SMX = cotrimoxazole, G = gentamicin, CPX = ciprofloxacin.