Table 4. Canonical pathways deregulated between patients and controls.

Canonical pathway	Significance (IPA)
Natural killer cell signaling	0.00000036
SAP/JNK Signaling	0.00000283
Leucocyte Extravasation Signaling	0.00000304
T Cell Receptor Signaling	0.0000178
Huntington's disease Signaling	0.0000334
Inositol Phosphate Metabolism	0.000105
Cell Cycle: G1/S Checkpoint Regulation	0.000114
Integrin Signaling	0.00019
Fc Epsilon RI Signaling	0.00021
B Cell Receptor Signaling	0.00025
Insulin Receptor Signaling	0.00054
JAK/Stat Signaling	0.001
p53 Signaling	0.001
PDGF Signaling	0.001
PTEN Signaling	0.001
Apoptosis Signaling	0.002
Nicotinate and Nicotinamide Metabolism	0.002
Axonal guidance Signaling	0.003
Ephrin receptor Signaling	0.004
Neurotrophin/Trk Signaling	0.004
PPARα/RXRα activation	0.005
NRF2-mediated oxidative stress response	0.008
TGF-β Signaling	0.01
Hypoxia Signaling in the Cardiovascular System	0.01
FGF Signaling	0.01
IL-2 Signaling	0.01
Wnt/β-catenin Signaling	0.01
ERK/MAPK Signaling	0.01
IGF-1 Signaling	0.01
Xenobiotic metabolism Signaling	0.02
IL-4 Signaling	0.03
Aryl Hydrocarbon Receptor Signaling	0.03
VEGF Signaling	0.03
Neuregulin Signaling	0.04
Protein Ubiquitination Pathway	0.04

Significance values as supplied by the IPA. Pathways in bold are pathways in which AKT1 participates.