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. 2012 Feb 29;7(2):e32531. doi: 10.1371/journal.pone.0032531

Figure 2. Expression of Cx31R42P induces necrotic cell death.

Figure 2

Quantification of small condensed nuclei (SN) (A) and apoptotic nuclei (B) in Hela and Cx31WT- (WT) or Cx31R42P- (R42P) stable cells growing at 26°C or 37°C. The rate of LDH release in these cells are also shown (C). (D) The rate of LDH release in Cx31R42P cells with either pan-caspase inhibitor z-VAD treatment (20 µM) or control solvent (DMSO) treatment. Two stars: P<0.01; three stars: P<0.001. Error bars represent SEM. Representative TEM images of Cx31WT cells (E) and Cx31R42P cells with SN (F) are shown. Scale bars = 5 µm.