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. 2012 Feb 29;7(2):e31267. doi: 10.1371/journal.pone.0031267

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Zhao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Genes significantly regulated by OVX+E2+CoP4 (17 genes; P<0.05) and/or OVX+E2+CyP4 (13 genes; P<0.05); red indicates up-regulated genes, green indicates down-regulated genes. (B) Hierarchical cluster diagrams: mitochondrial energy/redox metabolism related genes (top panel; 12 genes; P<0.05); insulin signaling/amyloid metabolism related genes (lower panel; 5 genes; P<0.05). Control Group = OVX; Group 1 = Sham-OVX; Group 5 = OVX+E2+CoP4; Group 6 = OVX+E2+CyP4. OVX: ovariectomy; E2: 17β-estradiol; CoP4: continuous P4; CyP4: cyclic P4.