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. 2012 Feb 29;7(2):e32737. doi: 10.1371/journal.pone.0032737

Figure 4. Mitochondrial distribution is altered in hippocampus of AD mice.

Figure 4

A. Neurons in APP/PS1 and PS1 mice exhibit increased sensitivity to NMDA treatment. Open circles – NTG; Open squares – APP; Close circles – APP/PS1; Triangles – PS1. B. Electron micrographs of an altered mitochondrial distribution in brain of APP/PS1 mouse 8 weeks old compared to NTG mouse of the same age. Asterisk denotes mitochondria with altered shape; arrowheads denote accumulation of mitochondria in neuropils. Scale bar, 5 µm (APP/PS1), 2 µm (NTG). C. Accumulation of normal and degenerating (asterisks) mitochondria in brain of APP mouse 12 weeks old. Scale bar, 500 nm.

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