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. 2012 Mar 1;23(5):945–954. doi: 10.1091/mbc.E11-08-0664

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© 2012 Naye et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Model for the role of BMP and FGF pathways in hepatopancreatic patterning. Bipotential endodermal progenitors, shown in the center of the scheme, can give rise to liver and pancreatic cells through the consecutive action of extrinsic signals secreted from the lateral mesoderm. Hepatic specification is determined by hhex and prox1 expression, whereas pdx1, ptf1a and hlxb9la are markers of pancreatic cell commitment.