Table 3.
Significant associations (p-values, p<.05) and selected effect sizes by SNP, CNB domain, and analysis
| SNP | Analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Abstraction & Mental Flexibility | Attention | Verbal Memory | Face Memory | Spatial Memory | Spatial Processing | Sensorimotor Dexterity | Emotion Processing | ||
| SNP8NRG221132 | Total | ||||||||
| NoDx | .015 | ||||||||
| NoDx & WRAT | .010 | ||||||||
|
| |||||||||
| SNP8NRG221533/rs35753505 | Total | ||||||||
| NoDx | .018 | ||||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| rs1081062° | Total | ||||||||
| NoDx | .022^ | .002^ | |||||||
| NoDx & WRAT | .002^ | ||||||||
|
| |||||||||
| rs1354335 | Total | .018^ | |||||||
| NoDx | |||||||||
| NoDx & WRAT | .041^ | ||||||||
|
| |||||||||
| rs1354336 | Total | .002^ | |||||||
| NoDx | .035^ | ||||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| SNP8NRG444511/rs13268724 | Total | .029^ | |||||||
| NoDx | |||||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| rs776401 | Total | .044^ | |||||||
| NoDx | |||||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| rs1473438 | Total | .032^ | |||||||
| NoDx | |||||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| rs726908 | Total | ||||||||
| NoDx | |||||||||
| NoDx & WRAT | .017 | ||||||||
|
| |||||||||
| rs10954855 | Total | .013 (+.31) | |||||||
| NoDx | .040 | .026 (+.26) | .015 | .002^ | |||||
| NoDx & WRAT | .027 (+.08) | .035 | |||||||
|
| |||||||||
| rs2439306 | Total | .041 | |||||||
| NoDx | |||||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| rs3924999 | Total | .031 (+.32) | .024 | ||||||
| NoDx | .030 (+.26) | ||||||||
| NoDx & WRAT | .014 (+.36) | ||||||||
|
| |||||||||
| rs2466060 | Total | .004 (+.42) | .026 | ||||||
| NoDx | .007 (+.51) | .037 | |||||||
| NoDx & WRAT | .005^ (+.73) | .024 | |||||||
|
| |||||||||
| rs2439272 | Total | .015 | .031 | .046 | .036 | ||||
| NoDx | .023 | ||||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| rs6468121 | Total | .049^ | .050 | ||||||
| NoDx | |||||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| rs2466058 | Total | ||||||||
| NoDx | .034 | ||||||||
| NoDx & WRAT | .021 | ||||||||
|
| |||||||||
| rs2466049 | Total | ||||||||
| NoDx | .035 | ||||||||
| NoDx & WRAT | .021 | ||||||||
|
| |||||||||
| rs2976525 | Total | ||||||||
| NoDx | .050 | .049 | |||||||
| NoDx & WRAT | |||||||||
|
| |||||||||
| rs4262285 | Total | ||||||||
| NoDx | |||||||||
| NoDx & WRAT | .047 | ||||||||
|
| |||||||||
| rs3735776 | Total | ||||||||
| NoDx | .035 | .021 | |||||||
| NoDx & WRAT | .004 | .015 | |||||||
|
| |||||||||
| rs4512342 | Total | ||||||||
| NoDx | |||||||||
| NoDx & WRAT | .024 | ||||||||
|
| |||||||||
| rs10503929 | Total | .032 (−.39) | .009^ | .029^ | .047 (−.18) | ||||
| NoDx | .035 (−.51) | .044 (−.32) | |||||||
| NoDx & WRAT | .006 (−.68) | .009^ | .020^ (−.36) | ||||||
|
| |||||||||
| rs3735781 | Total | ||||||||
| NoDx | |||||||||
| NoDx & WRAT | .047^ | ||||||||
Note: Only significant (p≤.05) associations are recorded. Effect sizes (within-family beta weight) for associations that were significant (p≤.05) for every analysis are provided in parentheses. A positive within-family beta weight value indicates that the minor allele confers a benefit to cognitive performance; a negative value indicates that the minor allele confers a detriment. Grey shading indicates associations that were significant (p≤.05) for every analysis.
Significant stratification and QTDT associations, all of which have greater within- than between-family beta weights.
The minor allele of rs1081062 was associated with reduced risk for affected status in the current study.