Table 2.
Means and standard deviations (SD) for variables describing sample divided by type of diagnostic conversion: CN to MCI (n=16) or MCI to dementia (n=11) over individualized follow-up.
| CN to MCI | MCI to Dementia | |||
|---|---|---|---|---|
|
| ||||
| Mean | SD | Mean | SD | |
| Age (years) (at baseline) | 79.9 | 6.1 | 80.8 | 5.0 |
| Education (years) | 14.3 | 3.5 | 15.8 | 1.7 |
| Mattis DRS total (at baseline) | 139.2 | 3.0 | 132.4* | 5.7 |
|
| ||||
| Longitudinal Measures | ||||
| Total high LEDS ratings | 3.1 | 3.2 | 4.7 | 2.1 |
| Diurnal cortisol (nmol/L) | 5.6 | 2.3 | 5.8 | 1.4 |
| CAR (% change) | 10.4 | 46.5 | 17.2 | 56.8 |
| Post-peak cortisol (nmol/L) | 3.4 | 1.9 | 3.2 | 1.1 |
| Follow-up interval (years) | 2.4 | 0.93 | 2.5 | 1.1 |
|
| ||||
| Percentage of Subjects | ||||
| MCI versus CN (at baseline) | 0.0 | 100.0 | ||
| Female | 75.0 | 54.5 | ||
| ≥1 APOE-e4 allele | 31.2 | 36.4 | ||
t-tests:
*
p<.05
CN = Cognitively Normal
MCI = Mild Cognitive Impairment
DRS = Mattis Dementia Rating Scale
LEDS = Life Events and Difficulties Schedule
Diurnal cortisol = mean of samples (awakening, 30 minutes later, 2 PM, 4 PM, bedtime)
CAR = Cortisol Awakening Response; percent change from awakening to 30 minutes later
Post-peak cortisol = mean of the 2 PM, 4 PM, and bedtime measures
APOE-e4 = Apolipoprotein-E e4 allele