Table 3.
Variables retained in the logistic regression analyses with conversion from MCI to dementia over individualized follow-up as the dependent variable and age at baseline (years), education (years), gender, presence or absence of APOE-e4 allele, total high LEDS ratings over follow-up, and a designated cortisol measure over follow-up as predictor variables.
| Variables | OR | 95% CI for OR | Effect Size a | Wald | p-value | |
|---|---|---|---|---|---|---|
| Model 1 b | ||||||
| Chi-square = 8.47 p<.01 | ||||||
| Total High LEDS Ratings | 1.67 | 1.11 | 2.52 | 2.47 | 6.08 | 0.01 |
|
| ||||||
| Model 2 c | ||||||
| Chi-square = 8.47 p<.01 | ||||||
| Total High LEDS Ratings | 1.67 | 1.11 | 2.52 | 2.47 | 6.08 | 0.01 |
|
| ||||||
| Model 3 d | ||||||
| Chi-square = 8.61 p<.01 | ||||||
| Total High LEDS Ratings | 1.66 | 1.11 | 2.47 | 2.49 | 6.16 | 0.01 |
Effect size = estimated regression coefficient / estimated standard error
Includes cortisol diurnal average: mean of all five samples throughout the day (nmol/L)
Includes cortisol post-peak average: mean of 2 PM, 4 PM, and bedtime samples in nmol/L
Includes CAR = Cortisol Awakening Response percent change from awakening to 30 minutes later
MCI = Mild Cognitive Impairment
APOE-e4 = Apolipoprotein-E e4 allele
LEDS = Life Events and Difficulties Schedule
OR = odds ratio
CI = confidence interval