Table 4.
Variables retained in logistic regression analyses with conversion from CN to MCI over individualized follow-up as the dependent variable and age at baseline (years), education (years), gender, presence or absence of APOE-e4 allele, total high LEDS ratings over follow-up, and a designated cortisol measure over follow-up as predictor variables.
| Variables | OR | 95% CI for OR | Effect Size a | Wald | p-value | |
|---|---|---|---|---|---|---|
| Model 1 b | ||||||
| Chi-square = 10.23 p<.01 | ||||||
| Age | 1.26 | 1.03 | 1.53 | 2.26 | 5.08 | 0.02 |
| Education | 0.74 | 0.54 | 1.00 | 1.95 | 3.81 | 0.05 |
|
| ||||||
| Model 2 c | ||||||
| Chi-square = 10.23 p<.01 | ||||||
| Age | 1.26 | 1.03 | 1.53 | 2.26 | 5.08 | 0.02 |
| Education | 0.74 | 0.54 | 1.00 | 1.95 | 3.81 | 0.05 |
|
| ||||||
| Model 3 d | ||||||
| Chi-square = 18.69 p<.001 | ||||||
| Age | 1.40 | 1.08 | 1.83 | 2.51 | 6.34 | 0.01 |
| Education | 0.54 | 0.32 | 0.92 | 2.25 | 5.08 | 0.02 |
| CAR percent change | 0.96 | 0.93 | 1.00 | 2.00 | 4.23 | 0.04 |
Effect size = estimated regression coefficient / estimated standard error
Includes cortisol diurnal average: mean of all five samples throughout the day (nmol/L)
Includes cortisol post-peak average: mean of 2 PM, 4 PM, and bedtime samples (nmol/L)
Includes CAR = Cortisol Awakening Response percent change from awakening to 30 minutes later
CN = cognitively normal
MCI = Mild Cognitive Impairment
APOE-e4 = Apolipoprotein-E e4 allele
LEDS = Life Events and Difficulties Schedule
OR = odds ratio
CI = confidence interval