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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Nanomedicine. 2011 Nov 22;8(6):1017–1025. doi: 10.1016/j.nano.2011.11.009

Figure 3. Resonance frequency shift following sandwich hybridization assay with the complementary probe-PCA3 target.

Figure 3

PCA3 target was used in a sandwich hybridization assay with the complementary ASO combination. Upper Left panel shows a scanning electron micrograph of a single clean RhNW before hybridization. Upper Right panel shows the same RhNW after the sandwich hybridization assay, with a substantial number of 50 nm AuNPs bound. Bottom panel shows a significant leftward shift (~200 kHz lower frequency) of the resonance peak upon particle binding.