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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Arthritis Rheum. 2011 Nov 10;64(4):1046–1056. doi: 10.1002/art.33454

Figure 5.

Figure 5

Poly (I-C) induced gene expression of murine Irf7−/− FLS and peritoneal macrophages. Mouse Irf7−/− FLS and peritoneal macrophages were stimulated with poly (I-C). QPCR analysis of cytokine gene expression was determined for RANTES, IP-10, IFNβ, MIP-1α, MMP-3, and IL-6 normalized to HPRT1. A. Poly (I-C) stimulation of Irf7−/− FLS resulted in increased induction of several pro-inflammatory cytokines compared with control (*p<0.05). B. Poly (I-C) stimulation of Irf7−/− peritoneal macrophages resulted in significantly less induction of IFNβ gene expression compared with control (*p<0.05).