Table 2.
Time 1 and Time 2 descriptive statistics for head shape measures (expressed as z-scoresa) among: children with diagnosed plagiocephaly or brachycephaly, confirmed on 3D imaging (all cases); children with brachycephaly, but not plagiocephaly (isolated brachycephaly); children without diagnosed plagiocephaly or brachycephaly, with some dysmorphology detected on 3D imaging (affected controls); and children without previously diagnosed plagiocephaly or brachycephaly and confirmed absence of cranial dysmorphology on 3D imaging (unaffected controls).
| Time 1 | ||||
|---|---|---|---|---|
| All Cases n=233 |
Isolated Brachycephaly Cases n=21 |
Affected Controls n=70 |
Unaffected Controls n=167 |
|
| Posterior Flatness (PF) | ||||
| Mean (SD) | 2.15 (1.43) | 1.29 (0.96) | 0.47 (1.20) | Ref |
| 5th percentile | −0.09 | −0.43 | −1.68 | −1.63 |
| 25th percentile | 1.15 | 0.68 | −0.34 | −0.66 |
| 50th percentile | 2.11 | 1.32 | 0.42 | −0.08 |
| 75th percentile | 2.96 | 1.92 | 1.13 | 0.68 |
| 95th percentile | 4.50 | 2.52 | 2.54 | 1.49 |
| Absolute Asymmetry Score (AAS) |
||||
| Mean (SD) | 3.19 (2.17) | 0.31 (0.93) | 0.56 (1.47) | Ref |
| 5th percentile | −0.32 | −1.01 | −1.18 | −1.17 |
| 25th percentile | 1.70 | −0.32 | −0.49 | −0.70 |
| 50th percentile | 3.13 | −0.05 | 0.27 | −0.23 |
| 75th percentile | 4.61 | 1.18 | 1.61 | 0.46 |
| 95th percentile | 6.84 | 1.51 | 3.07 | 1.92 |
| Oblique Cranial Length Ratio (aOCLR) |
||||
| Mean (SD) | 1.17 (1.22) | −0.08 (0.40) | 0.35 (2.35) | Ref |
| 5th percentile | −0.41 | −0.61 | −0.59 | −0.68 |
| 25th percentile | 0.40 | −0.41 | −0.29 | −0.49 |
| 50th percentile | 1.01 | −0.09 | −0.02 | −0.28 |
| 75th percentile | 1.74 | 0.15 | 0.42 | 0.25 |
| 95th percentile | 3.09 | 0.56 | 1.69 | 1.15 |
| Cephalic Index (CI) | ||||
| Mean (SD) | 2.48 (1.46) | 3.66 (0.80) | 1.19 (1.33) | Ref |
| 5th percentile | 0.16 | 2.71 | −1.02 | −1.69 |
| 25th percentile | 1.40 | 2.88 | 0.14 | −0.69 |
| 50th percentile | 2.52 | 3.81 | 2.25 | 0.06 |
| 75th percentile | 3.62 | 4.13 | 2.10 | 0.71 |
| 95th percentile | 4.79 | 4.96 | 3.34 | 1.69 |
|
| ||||
| Time 2 | ||||
| All Cases n=221 |
Isolated Brachycephaly Cases n=20 |
Affected Controls n=68 |
Unaffected Controls n=161 |
|
|
| ||||
| Posterior Flatness (PF) | ||||
| Mean (SD) | 1.36 (1.12) | 1.0 (1.30) | 0.32 (0.95) | −0.30 (0.94) |
| 5th percentile | −0.42 | −1.64 | −0.83 | −1.68 |
| 25th percentile | 0.72 | 0.22 | −0.46 | −0.80 |
| 50th percentile | 1.33 | 0.98 | 0.23 | −0.41 |
| 75th percentile | 2.07 | 1.99 | 0.69 | 0.25 |
| 95th percentile | 3.31 | 2.95 | 2.24 | 1.26 |
| Absolute Asymmetry Score (AAS) |
||||
| Mean (SD) | 1.52 (1.62) | 0.40 (1.35) | 0.12 (1.12) | −0.19 (0.85) |
| 5th percentile | −0.83 | −0.87 | −1.11 | −1.14 |
| 25th percentile | 0.20 | −0.65 | −0.61 | −0.87 |
| 50th percentile | 1.44 | −0.15 | −0.10 | −0.33 |
| 75th percentile | 2.46 | 1.37 | 0.47 | 0.31 |
| 95th percentile | 4.15 | 2.97 | 2.22 | 1.30 |
| Oblique Cranial Length Ratio (aOCLR)b |
||||
| Mean (SD) | 0.94 (0.84) | −0.19 (0.41) | 0.05 (0.98) | −0.23 (0.35) |
| 5th percentile | −0.49 | −0.69 | −0.57 | −0.62 |
| 25th percentile | 0.37 | −0.50 | −0.39 | −0.49 |
| 50th percentile | 0.92 | −0.14 | −0.15 | −0.28 |
| 75th percentile | 1.51 | −0.01 | 0.26 | −0.04 |
| 95th percentile | 2.38 | 0.71 | 0.73 | 0.39 |
| Cephalic Index (CI) | ||||
| Mean (SD) | 1.76 (1.31) | 2.32 (0.73) | 0.65 (1.27) | −0.46 (0.88) |
| 5th percentile | −0.13 | 1.18 | −1.02 | −1.76 |
| 25th percentile | 0.86 | 1.88 | −0.43 | −1.10 |
| 50th percentile | 1.68 | 2.26 | 0.62 | −0.43 |
| 75th percentile | 2.53 | 2.80 | 1.37 | 0.09 |
| 95th percentile | 3.97 | 3.66 | 3.02 | 1.00 |
Scores are expressed in z-score units (mean = 0, standard deviation = 1) using Time 1 scores for unaffected controls as the reference group (e.g., z = observed score - Time 1 unaffected control group mean / Time 1 unaffected control group standard deviation).
The aOCLR could not be used for 1 case at Time 2 due to poor 3D photo quality. This did not affect other measures.