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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Thromb Haemost. 2012 Jan;10(1):107–115. doi: 10.1111/j.1538-7836.2011.04545.x

Figure 1. Factor VIII has eight disulfide bonds in its mature form.

Figure 1

The A1 and A2 domains of the heavy chain and A3 domain of the light chain contain two disulfide bonds each while the C1 and C2 domains of the light chain contain one disulfide bond each (A). The positions of the free and disulfide paired cysteines of FVIII are shown in yellow in this X-ray crystal structure representation (courtesy of Dr. B.L.Stoddard, Fred Hutchinson Cancer Research Center, Seattle, WA) (B). Seven of these disulfides are buried in the hydrophobic core whereas the disulfide bridge between C1899 and C1903 is exposed to the surface.