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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Oct 29;71(11):996–1005. doi: 10.1016/j.biopsych.2011.09.030

Figure 3. Morphological changes in layer V pyramidal cells in BDNF Val/Met and Met/Met mice are associated with a reduction in the frequency and amplitude of 5-HT and hypocretin (hcrt)-induced EPSCs.

Figure 3

(A) Sample traces of EPSCs in mPFC layer V pyramidal cells fromVal/Val, Val/Met and Met/Met mice; (B) Mean frequencies ± SEM of 5-HT- and hypocretin-induced EPSCs are reduced in Val/Met and Met/Met groups compared with that of the Val/Val group. Asterisk indicates statistical significance (*P < 0.05, **P < 0.01). (c) Cumulative probability distributions showing a significant decrease in EPSC amplitude in the Met/Met group for both 5-HT and Hcrt (P < 0.0001 for 5-HT, KS-z value = 8.8; p < 0.0001 for Hcrt, KS-z value = 7.5).