Skip to main content
. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Neuroimaging. 2011 Aug 19;22(3):e12–e19. doi: 10.1111/j.1552-6569.2011.00629.x

Table 4.

Pairwise group comparisons of spinal cord volumes among progressive MS and relapsing MS or healthy control groups

Region Normalization approach PP/SP vs. controls: p-value PP/SP vs. RR/CIS: p-value
C2-3 Normalized to # of slices (mm3) 0.00011 0.00062
Normalized to # of slices and ICV** 0.0020 0.0061
Cervical cord Raw volume (mm3) 0.0025 0.0035
Normalized to ICV** 0.0031 0.0032
Normalized to # of slices (mm3) 0.0004 0.0005
Normalized to #of slices and ICV** 0.0042 0.0036
Thoracic cord Raw volume (mm3) 0.015 0.040
Normalized to ICV** 0.032 0.071
Normalized to #of slices (mm3) 0.0078 0.037
Normalized to #of slices and ICV** 0.034 0.11
Whole cord Raw volume (mm3) 0.0046 0.010
Normalized to ICV** 0.0072 0.013
Normalized to #of slices (mm3) 0.0017 0.0061
Normalized to #of slices and ICV** 0.0098 0.023

ICV=intracranial volume, PP= primary progressive, SP=secondary progressive, RR=relapsing remitting, CIS=clinically isolated syndrome. Reported p-values are age-adjusted p-values from pairwise comparisons of groups with Bonferonni correction to account for multiple comparisons.

**

unitless measure.