Table 5.
Correlations between MRI-based spinal cord volumes and neurologic disability
| Region | Volume | Correlation (rs) with EDSS |
p- value |
Correlation (rs) with T25FW |
p- value |
|---|---|---|---|---|---|
| C2-3 | Normalized to # of slices | −0.509 | 0.002 | −0.424 | 0.012 |
| Normalized to # of slices and ICV | −0.451 | 0.007 | −0.400 | 0.019 | |
| Cervical cord | Raw | −0.401 | 0.019 | −0.272 | 0.120 |
| Normalized to ICV | −0.428 | 0.012 | −0.297 | 0.088 | |
| Normalized to # of slices | −0.450 | 0.008 | −0.352 | 0.041 | |
| Normalized to # of slices and ICV | −0.420 | 0.013 | −0.334 | 0.054 | |
| Thoracic cord | Raw | −0.296 | 0.089 | −0.269 | 0.124 |
| Normalized to ICV | −0.298 | 0.087 | −0.295 | 0.091 | |
| Normalized to # of slices | −0.258 | 0.141 | −0.229 | 0.193 | |
| Normalized to # of slices and ICV | −0.286 | 0.102 | −0.209 | 0.237 | |
| Whole cord | Raw | −0.330 | 0.057 | −0.268 | 0.125 |
| Normalized to ICV | −0.373 | 0.030 | −0.303 | 0.081 | |
| Normalized to # of slices | −0.339 | 0.050 | −0.230 | 0.191 | |
| Normalized to # of slices and ICV | −0.354 | 0.040 | −0.256 | 0.144 |
ICV=intracranial volume, EDSS=Expanded Disability Status Scale, T25FW=Timed 25 Foot Walk, rs=Spearman’s correlation coefficient.