Table 1.

Characteristics of the studied sample, by Cohort and gender.

	Original Cohort		Offspring Cohort
	Males	Females	Males	Females
Variable	Mean ±S.D	Mean ±S.D	Mean ±S.D	Mean ±S.D
N*	144	261	962	1362
Age (yrs)	77.3 ±3.6	77.7 ±4.0	61.3 ±9.2	60.3 ±9.3
Height (meter)	1.70 ±0.07	1.56 ±0.06	1.74 ±0.07	1.61 ±0.06
Weight (kg)	79.2 ±12.4	65.8 ±12.1	86.6 ±13.0	70.8 ±14.2
BMI (kg/m2)	27.4 ±3.8	27.0 ±4.9	28.4 ±3.8	27.3 ±5.3
Premenopausal or Currently on Estrogen, N (%)	-	19 (7.28%)	-	625 (45.88%)
BMD (g/cm2)
Femoral neck	0.866 ± 0.125	0.723 ± 0.119	0.966 ± 0.132	0.868 ± 0.140
Total Femoral	0.937 ± 0.141	0.760 ± 0.129	1.036 ± 0.140	0.911 ± 0.147
Trochanter	0.826 ± 0.133	0.624 ± 0.121	0.877 ± 0.136	0.714 ± 0.133
Lumbar spine	1.313 ± 0.213	1.053 ± 0.211	1.311 ± 0.197	1.153 ± 0.197
Quantitative Ultrasound
BUA (dB/MHz)	77.78 ± 22.43	53.37 ± 16.53	83.14 ± 19.03	71.40 ± 18.44
SOS (m/s)	1546.25 ± 38.19	1513.49 ± 30.12	1559.73 ± 34.27	1549.60 ± 35.14
Bone geometry
NSA (degrees)	131.7 ±6.2	128.0 ±5.5	129.4 ±4.9	127.5 ±5.2
FNL (cm)	5.4 ±0.8	4.6 ±0.6	6.0 ±0.8	5.2 ±0.6
Narrow Neck Outer diameter (cm)	3.4 ±0.3	2.9 ±0.3	3.8 ±0.5	3.3 ±0.4
Narrow Neck CSA (cm2)	2.4 ±0.4	1.8 ±0.4	2.8 ±0.4	2.3 ±0.4
Narrow Neck Section modulus (cm3)	1.4 ±0.3	0.9 ±0.2	1.8 ±0.4	1.3 ±0.3
Narrow Neck Buckling Ratio	12.9 ±3.2	13.6 ±4.7	11.4 ±6.2	10.4 ±6.0
Shaft Outer diameter (cm)	3.2 ±0.2	3.0 ±0.2	3.5 ±0.4	3.2 ±0.4
Shaft CSA (cm2)	4.2 ±0.6	2.8 ±0.5	4.5 ±0.6	3.3 ±0.5
Shaft Section modulus (cm3)	2.6 ±0.4	1.6 ±0.3	2.8 ±0.5	1.9 ±0.4
Shaft Buckling Ratio	3.6 ±0.9	4.7 ±1.3	3.9 ±1.1	4.7 ±1.5
Muscle mass
Leg Lean mass (kg)	17.04 ±2.23	11.53 ±1.54	17.21 ±2.21	11.57 ±1.57

^*number of subjects for all available participants with both genotypes and phenotypes.