Table 5.

Gene networks associated with skeletal and muscular system development and function inferred from GWAS of principal components.

PC	p-value*	# of molecules in the network
PC1 (combined)	9.05*10−5 − 8.72*10−3	4
PC2 (combined)	2.55*10−3 − 7.54*10−3	6
PC4 (combined)	7.71*10−5 − 4.08*10−3	8
PC1 (women)	4.64*10−4 − 1.51*10−2	6
PC2 (women)	7.57*10−4 − 1.05*10−2	8
PC4 (women)	4.66*10−3 − 4.17*10−2	4

^*p-value for enrichment analysis; ranges correspond to the different specific lower level functions or sub-categories (e.g. osteopenia, ossification and mineralization) that are classified within the “skeletal and muscular system development and function”