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. 2011 Dec 12;92(3):345–361. doi: 10.1038/labinvest.2011.168

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Copyright © 2012 United States and Canadian Academy of Pathology, Inc.

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Non-immune-mediated granuloma cells also express carboxypeptidase-M (CPM). (a and b) Besides epithelioid macrophages, foreign body giant cells (arrows) of lung amyliodoma (a) and surgical suture-associated multinucleate macrophages (b) show CPM expression (purple cells). (c) Palisade epithelioid cells (EPCs) of granulomatous necrotizing (N) panniculitis always express CPM. Arrows indicate positively labeled epithelioid cells (purple). (d) As shown in the present intestinal biopsy specimen harboring Crohn's disease, CPM-immunohistochemistry (IHC) readily and reliably ‘picks up' the lesional granuloma macrophage clusters (arrows, brown cells) from the rest of CD163⁺ non-granulomatous macrophages.