Table 4.

Polyglutamine Disease Models in Flies

Model	Transgene	Features	Relevance	References
HD	hHtt-ex1-2Q, -75Q, -120Q	Expressed in the eye	Htt neurotox.	[5]
	hHtt-ex1-20Q, -93Q	First 90 a.a.	Htt neurotox.	[73]
	hHtt-1-171-18Q, -138Q	First 171 a.a.	Htt neurotox.	[144]
	hHtt-1-336-16Q, -128Q	First 336 a.a.	Htt neurotox.	[113]
	hHtt-1-548-0Q, -128Q	First 548 a.a.	Htt neurotox.	[74]
	hHtt-ex1-18Q, -48Q, -152Q	EGFP fusions	Htt aggregation and neurotox.	[120]
	hHtt-ex1-25Q, -46Q, -72Q, -103Q	EGFP fusions	Htt aggregation and neurotox.	[121]
	hHttFL-16Q, -128Q	Full-length	Htt neurotox.and neurobiology	[76]
SCA1	hSCA1-2Q, -30Q, -82Q	Full-length	Atx1 neurotox.and neurobiology	[6]
SCA2	hSCA2 and dSCA2	Full-length and deletion constructs	Atx2 function	[145]
SCA3	hSCA3-27Q, -78Q	C-terminal fragment	Atx3 neurotox.	[4]
	hSCA3-65Q(NLS), hSCA-77Q(NES)	C-terminal fragment	Atx3 neurotox.and axonal transport	[30]
	hSCA3-79Q	C-terminal fragment	Atx3 neurotox.	[146]
	hSCA3FL-27Q, -78Q, -84Q	Full-length	Atx3 neurotox.	[147]
SCA7	hSCA7-10Q, -102Q	First 232 a.a.	Atx7 neurotox.	[148]
DRPL	hAtrophin1-26Q,- 65Q	First 917 a.a	At1 neurotox.	[149]
SBMA	hAndrogen Receptor-112Q	N-terminal fragment	AR neurotox.	[150]
	hAndrogen Receptor-52Q	Full-length	AR neurotox.	[151]
PolyQ	20Q, 127Q	HA tagged	polyQ neurotox.	[8]
	22Q, 108Q	Myc/Flag tagged	polyQ neurotox.	[7]