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Domain organization and catalytic cycle of human copper-ATPases (ATP7A and ATP7B).
A: membrane topology and domain organization of Cu-ATPase; MBDs, metal-binding domains; A-domain, the actuator domain; P-domain, phosphorylation domain; N-domain, nucleotide-binding domain. Modified from Lutsenko et al. Physiol Rev. 2007, 87: 1011. Used with permission.
