Table 2.

Biomarker performance for distinguishing different disease states

Biomarker	Time since admission h	AKI			AKI RIFLE categories
		sustained vs. no AKI	sustained vs. transient	transient vs. no AKI	failure vs. injury	failure vs. risk	injury vs. risk
pNGAL	0	<0.0001	–	–	–	–	–
	4	<0.0001	–	0.001	–	–	–
	8	<0.0001	–	0.009	–	0.01	–
	24	<0.0001	–	–	–	0.02	–
	36	<0.0001	0.0002	–	–	0.03	–
	48	<0.0001	0.02	–	–	0.03	–
	60	<0.0001	–	–	–	–	–
	72	<0.0001	–	–	–	0.03	–
uNGAL	0	<0.0001	0.02	–	–	–	–
	4	<0.0001	0.01	–	–	0.04	–
	8	<0.0001	0.002	–	–	–	–
	24	<0.0001	0.004	–	–	0.02	0.03
	36	<0.0001	<0.0001	–	–	–	–
	48	<0.0001	0.002	–	–	–	–
	60	<0.0001	0.0008	–	–	–	–
	72	<0.0001	0.01	–	–	0.049	–
pCyC	0	<0.0001	–	–	–	–	–
	4	<0.0001	–	0.02	–	–	–
	8	<0.0001	–	–	–	–	–
	24	<0.0001	0.005	–	–	–	–
	36	<0.0001	<0.0001	–	–	–	–
	48	<0.0001	0.0001	–	–	–	–
	60	<0.0001	0.01	–	–	–	–
	72	<0.0001	–	–	–	–	–
uCyC	0	–	–	–	–	–	–
	4	<0.0001	0.03	–	–	–	–
	8	<0.0001	0.04	–	–	–	–
	24	<0.0001	–	–	–	–	–
	36	0.0002	–	–	–	–	–
	48	<0.0001	–	–	–	–	–
	60	<0.0001	–	–	–	–	–
	72	<0.0001	–	–	–	–	–

− = Nonsignificant.