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The effect of KIOM-MA and KIOM-MA128 on scratching behavior. KIOM-MA or KIOM-MA128 was administered to the mice as described in the Materials and Methods. Simultaneously, we counted the number of times the mice scratched skin lesions for 30 min on 14 consecutive days. KIOM-MA and KIOM-MA128 caused a decrease in the scratching behavior, which was accompanied by improvement of skin eruptions. *P < 0.05, **P < 0.01, when compared with untreated group.
