Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
PXR protects the vasculature against chemical and oxidative insults. Activation of PXR in endothelial cells and SMC induces transcription of Phase I and II drug-metabolizing enzymes and transporters, e.g. CYP3A and GSTs, consequently altering metabolic handling and enhancing endogenous homeostatic mediator production, e.g. EETs in the vasculature. Oxidative stress response genes, e.g. GPx, are also up-regulated, which with GSTs can protect against oxidative damage.
