Table 4.

Baseline and week 16 values and changes in exploratory efficacy parameters

Pt ID	BL	Week 16	Δ	BL	Week 16	Δ	BL	Week 16	Δ
	6-min Walk distance (m)			Exercise treadmill test (metabolic equivalents)			Right ventricular ejection fraction (3-dimensional) (%)
1	411	472	61	6.1	6.4	0.3	23	17	−6
2	585	541	−44	6.3	7.8	1.5	28	38	10
3	481	495	14	7.3	8.9	1.6	27	36	9
4	492	421	−71	4.6	6.4	1.8	33	46	13
5	666	682	16	11.0	11.0	0.0	34	36	2
6	398	445	47	6.1	6.8	0.7	22	31	9
7	349	389	40	5.2	5.3	0.1	16	30	14
8	265	288	23	4.1	4.4	0.3	41	43	2
9a	262	296	34	3.3	3.7	0.4	19	20	1
10	363	448	85	6.3	8.9	2.6	18	16	−2
11	473	437	−36	5.6	4.8	−0.8	17	13	−4
Median	411	445	23	6.1	6.4	0.4	23	31	2
Min	262	296	−71	3.3	3.7	−0.8	16	13	−6
Max	666	682	85	11.0	11.0	2.6	41	46	14
P value			0.33			0.02			0.09

	Mean pulmonary arterial pressure (mm Hg)			Cardiac output/cardiac index (l/min)/(l/min/m2)			Pulmonary vascular resistance index (Units × m2)
1	53	61	8	3.4/1.9	2.8/1.6	−0.6/−0.3	22	34	12
2	63	59	−4	4.6/2.4	4.3/2.3	−0.3/−0.1	21	21	0.0
3	55	47	−8	4.8/2.4	4.6/2.3	−0.2/−0.1	17	17	0.0
4	48	40	−8	7.1/4.2	6.4/3.8	−0.7/−0.4	9	8	−1.0
5	36	35	−1	7.6/3.6	7.0/3.4	−0.6/−0.2	7	7	0.0
6	45	43	−2	4.6/3.1	3.2/2.2	−1.4/−0.9	12	16	4
7	51	36	−15	6.5/3.5	5.5/2.9	−1.0/−0.6	11	8	−3.0
8	41	35	−6	9.3/5.0	6.5/3.5	−2.8/−1.5	5	9	4
9a	48	53	5	3.7/2.3	3.6/2.2	−0.1/−0.1	20	18a	−2.0
10	58	55	−3	2.6/1.9	2.4/1.7	−0.2/−0.2	25	24	−1.0
11	64	64	0	2.7/1.7	2.2/1.5	−0.5/−0.2	31	35	4.0
Median	51	47	−3	4.6/2.4	4.3/2.3	−0.6/−0.2	17	17	0.0
Min	36	35	−15	2.6/1.7	2.2/1.5	−2.8/−1.5	5	7	0.0
Max	64	64	8	9.3/5.0	7.0/3.8	0.1/−0.1	31	35	12
P value			0.11			<0.01b			0.62

Δ, change; BL, baseline.

^aTests delayed 4 weeks because of severe respiratory infection.

^bApplies to both cardiac output and cardiac index.