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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: N Am J Med Sci (Boston). 2011 Oct 1;4(4):183–190. doi: 10.7156/v4i4p183

Figure 1. Schematic Representation of Human AGT Gene and Protein.

Figure 1

Human angiotensinogen (AGT) gene contains 5 exons. Exon 2 encodes the majority of the protein. After the removal of a 33 aa signal peptide, the 452 aa mature AGT is secreted. Cleavage of mature AGT by renin gives a decapeptide, AngI, and the 442 aa des(AngI)-AGT. AngI is further cleaved by angiotensin-converting enzyme (ACE) into an octapeptide, AngII. Two cysteines at 18 and 138 form a disulphide bridge (Cys18-Cys138) that confers a conformational change allowing access of renin to the AngI cleavage site of AGT. Diagrams were drawn proportional to actual gene and protein size based on the University of California Santa Cruz Human Genome Browser Feb 2009 Assembly. UTR: untranslated region; CDS: coding sequences; ACE: angiotensin-converting enzyme.