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COR treatment effects on gross histopathology at 4 days following NMDA injection into the rat motor cortex, as revealed by cresyl violet staining. Animals treated with 5% tween (a-b) or 400 mg/kg of COR (c-d). COR treatment reduced mononuclear cell infiltration and tissue cavitation (c-d) compared to vehicle animals (a-b). Arrows point to mononuclear cells (d). Asterisks indicate the excitotoxic necrotic center. Scale bars: (a–c) (300 μm); (b–d) (50 μm).
