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. 2012 Feb 12;2012:836759. doi: 10.1155/2012/836759

Figure 7.

Figure 7

Systemic treatment with the PTP inhibitor attenuates SHP-1 expression and increases eNOS and myocardial capillary density in db/db mice. (a) Western blot analysis showing that treatment with BMOV for 2 weeks leads to a significant suppression of SHP-1 expression in the db/db mice compared to db/db control without BMOV (n = 3 mice, *P < 0.05). (b) Western blot analysis showing that treatment with BMOV for 2 weeks results in a significant increase in eNOS expression in the db/db mice compared to db/db control (n = 3-4 mice, *P < 0.05). (c) Myocardial capillary density was significantly increased in the BMOV-treated db/db mice compared to db/db control with BMOV (n = 8, *P < 0.05). (d) Quantitation of areas of vessel outgrowth showing Ang-1-induced vessel explants sprouting is significantly improved in the BMOV-treated db/db mice compared to db/db control group (n = 4–8 mice, *P < 0.05).