Table 2.

Hazard Ratio of Incident Hypertension (891 Cases) Among 2,153 Nonhypertensive Calcium Plus Vitamin D Trial Participants With Available Baseline 25-Hydroxyvitamin D Measurements (nmol/L) Among Women Recruited Into the Women’s Health Initiative Between 1993 and 1998

	Incident Hypertension by 25(OH)D Quartilea								P Valueb
	Quartile 1 (Median, 26.2 nmol/L; Range, 1–<34.4)		Quartile 2 (Median, 41.4 nmol/L; Range, 34.4–<47.7)		Quartile 3 (Median, 55.9 nmol/L; Range, 47.7–<64.7)		Quartile 4 (Median, 77.6 nmol/L; Range, ≥64.7)
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Model 1c	1.00	Referent	0.90	0.65, 1.25	0.70	0.51, 0.96	0.81	0.59, 1.11	0.20
Model 2d	1.00	Referent	0.92	0.64, 1.33	0.67	0.46, 0.96	0.86	0.61, 1.23	0.17
Model 3e	1.00	Referent	0.91	0.62, 1.32	0.66	0.46, 0.96	0.86	0.60, 1.23	0.19

Abbreviations: CI, confidence interval; HR, hazard ratio; 25(OH)D, 25-hydroxyvitamin D₃.

^aQuartile 1: 234 cases, 2,686 person-years; quartile 2: 224 cases, 3,133 person-years; quartile 3: 220 cases, 3,217 person-years; quartile 4: 213 cases, 3,258 person-years.

^bP value for overall association.

^cControlled for age, race/ethnicity, clinical center, and month of blood draw.

^dControlled for the variables in model 1 plus calcium/vitamin D trial assignment, education, alcohol intake, smoking, body mass index, physical activity, blood pressure at enrollment, history of cardiovascular disease, and history of diabetes.

^eControlled for the variables in model 2 and for dietary/supplemental vitamin D intake.