Fig. 1.
Total whole knee counts (as % dose) and knee joint tissue counts (as % total knee counts) after a single intra-articular (IA) dose of [125I]LUB:1 to naïve rats. Naïve rats were administered 20 μg/knee of [125I]LUB:1 and knees were collected at the time points described in the text and Table I (studies 1 and 2). (a) Individual animal total knee counts obtained by gamma counting were expressed as the percentage of total administered dose (open circles) and fitted simultaneously using the three-compartment model (solid line), as described in the text. Insert shows data up to 24 h post-dose. (b) For the 336 h (14 days) and 672 h (28 days) time points, joint tissues were further dissected into tibial plateau (TP), femoral condyle (FC), meniscus, patella, and synovium (n = 3 per time point) crude sections, gamma counting of these specific sections was conducted, the section counts were expressed as the percentage of total knee counts for each individual animal, and the mean and range values were plotted