Table II.
Radioactive Equivalent Concentrations of [125I]LUB:1 and Counts, as % Dose, in Liver, Spleen, Kidney, and Knee After a Single IA Dose of ~20 μg/Knee to Lewis Rats
| 6 h | 24 h | |||
|---|---|---|---|---|
| Mean concentration (ng eq/g) | Radioactivity (% dose) | Mean concentration (ng eq/g) | Radioactivity (% dose) | |
| Kidney | 98 | 1.29 | 7 | 0.09 |
| Knee | 1,320 | 27.7 | 132 | 2.37 |
| Liver | 22 | 1.17 | 2 | 0.13 |
| Spleen | 25 | 0.09 | 2 | 0.01 |
Naïve Lewis rats (n = 5 per time point) were administered a single IA dose of ~20 μg/knee of [125I]LUB:1 into the right knee (study 3 in Table I) and tissues were analyzed for total counts and the radioactive equivalent concentrations by gamma counting, as described in the text