Table III.
Individual Animal and Mean Plasma PK Parameters of [125I]LUB:1 After a Single 0.5 mg/kg IV Dose to Lewis Rats
| Animal_ID | C 2min (ng eq/mL) | AUC0−∞ (ng eq∙h/mL) | CL (mL/h/kg) | Vdss (mL/kg) | t 1/2 (h) |
|---|---|---|---|---|---|
| Rat 1 | 1,823 | 3,231 | 155 | 865 | 8.79 |
| Rat 2 | 1,808 | 2,979 | 168 | 628 | 5.05 |
| Rat 3 | 1,752 | 3,049 | 164 | 784 | 6.42 |
| Rat 4 | 1,805 | 3,412 | 147 | 566 | 5.01 |
| Rat 5 | 1,846 | 3,683 | 136 | 726 | 8.03 |
| Mean | 1,807 | 3,271 | 154 | 714 | 6.66 |
| SD | 35 | 285 | 13.0 | 120 | 1.72 |
Naïve Lewis rats (n = 5) were administered a single IV dose of 0.5 mg/kg of [125I]LUB:1 into jugular vein (study 5 in Table I), plasma samples were analyzed for radioactive equivalent concentrations by gamma counting and individual animal PK parameters were determined, as described in the text