Fig. 1.

Synthesis of AZ66. Reagents and conditions: a NH₄SCN, H₂O, reflux, 4 h; b Br₂, CHCl₃, 1 h at 0°C, reflux, 2 h; c KOH; d Gl. acetic acid; e carbonyl 1,1′ diimidazole, THF, reflux, 3 h; f 1,4-dibromopentane, K₂CO₃, DMF, 60°C, 3 h; g cyclohexyl piperazine, K₂CO₃, TBAI, ACN, reflux, 6 h