Fig. 5.

Effects of AZ66 on the expression of behavioral sensitization to methamphetamine. Male, Swiss Webster mice were injected (i.p.) with saline or methamphetamine (Meth; 1 mg/kg) once a day for 7 days (days 1–7). Following an 8-day drug-free period (day 15), mice were injected (i.p.) with saline or AZ66 (10 or 20 mg/kg), followed 15 min later with methamphetamine (1 mg/kg, Meth). Pretreatment with AZ66 (10 or 20 mg/kg) on day 15 significantly blocked the expression of sensitization. Data are represented as mean ± SEM. ***p < 0.001 day 15 vs. day 1 and ##p < 0.01, ###p < 0.001 day 15 vs. methamphetamine sensitized group (Meth/Saline + Meth), post hoc Bonferroni’s tests