Table I.
Treatment Schedule for Sensitization Experiments
| Development of sensitization | Expression of sensitization | ||||||
|---|---|---|---|---|---|---|---|
| Group | Days 1–7 | Days 8–14 | Day 15 | Group | Days 1–7 | Days 8–14 | Day 15 |
| 1 | Sal + Sal | NT | Sal + Meth | 1 | Sal + Sal | NT | Sal + Meth |
| 2 | Sal + Meth | NT | Sal + Meth | 2 | Sal + Sal | NT | AZ(10 mg/kg) + Meth |
| 3 | AZ (10 mg/kg) + Meth | NT | Sal + Meth | 3 | Sal + Sal | NT | AZ (20 mg/kg) + Meth |
| 4 | AZ (20 mg/kg) + Meth | NT | Sal + Meth | 4 | Sal + Meth | NT | Sal + Meth |
| 5 | AZ (10 mg/kg) + Sal | NT | Sal + Meth | 6 | Sal + Meth | NT | AZ (10 mg/kg) + Meth |
| 6 | AZ (20 mg/kg) + Sal | NT | Sal + Meth | 7 | Sal + Meth | NT | AZ (20 mg/kg) + Meth |
n = 6–10/group. All compounds were administered intraperitoneally
NT no treatment, Meth methamphetamine (1 mg/kg), Sal saline, AZ AZ66