Table I.
Bidirectional Transport Permeability and Metabolism of B/W/OA in Caco-2 Cell Monolayer Model (n = 3)
| Loading concentration (μM) | A to B | B to A | ||
|---|---|---|---|---|
| P app (×10−6 cm/s) | % of metabolism | P app (×10−6 cm/s) | % of metabolism | |
| 3.55 (B) (26) | N.D. | N.A. | N.D. | N.A. |
| 7.98 (B) (26) | N.D. | 76.9 | N.D. | 45.3 |
| 23.7 (B) (26) | 3.80 ± 0.48 | 51.8 | 4.03 ± 0.15 | 26.3 |
| 3.79 (W) | N.D. | 95.9 ± 2.16 | N.D. | 53.0 ± 0.34 |
| 7.58 (W) | 10.5 ± 2.91 | 53.1 ± 5.13 | 7.29 ± 1.25 | 43.8 ± 1.31 |
| 18.9 (W) | 12.6 ± 0.55 | 32.1 ± 0.98 | 8.96 ± 1.36 | 28.5 ± 1.35 |
| 3.47 (OA) | N.D. | 99.8 ± 0.02 | N.D. | 79.0 ± 1.09 |
| 6.94 (OA) | 2.91 ± 0.44 | 90.3 ± 0.20 | 4.43 ± 0.90 | 67.7 ± 1.14 |
| 17.4 (OA) | 5.73 ± 0.19 | 55.6 ± 1.91 | 5.62 ± 0.55 | 36.8 ± 1.55 |