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. 2011 Dec 14;14(1):23–34. doi: 10.1208/s12248-011-9310-9

Table IV.

Enzyme Kinetic Parameters of the Glucuronidation for B/W/OA in Various Intestinal Fractions and UGTs (n = 3)

Fraction/UGT B W OA
V max (nmol/min/mg) K m (μM) Clint (×103 μl/min/mg) V max (nmol/min/mg) K m (μM) Clint (×103 μl/min/mg) V max (nmol/min/mg) K m (μM) Clint (×103 μl/min/mg)
HIM 41.9 ± 1.92 (27) 93.9 ± 7.71 (27) 0.446 (27) 5.13 ± 0.16 1.23 ± 0.17 4.17 5.24 ± 0.24 1.04 ± 0.23 5.04
RIS9 6.15 ± 0.85 46.7 ± 10.2 0.131 8.05 ± 0.56 44.0 ± 4.85 0.182 3.87 ± 0.14 9.95 ± 0.96 0.388
1A8 3.17 ± 0.27 (27) 19.5 ± 4.80 (27) 0.163 (27) 8.86 ± 0.54 9.37 ± 1.54 0.945 7.65 ± 0.75 6.96 ± 1.99 1.10
1A10 0.38 ± 0.03 5.40 ± 1.49 0.710 5.21 ± 0.29 12.1 ± 1.61 0.431 7.29 ± 0.33 4.81 ± 0.68 1.52