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. Author manuscript; available in PMC: 2012 Aug 19.
Published in final edited form as: Cell. 2011 Aug 19;146(4):555–567. doi: 10.1016/j.cell.2011.07.012

Figure 4. The chromosome ring facilitates spindle assembly.

Figure 4

(A) Two types of initial chromosome distribution (Random and Toroidal) and corresponding dynamics of kinetochore capture predicted in our computer simulations. The toroidal distribution provides a clear kinetic advantage. (B–C) Mitosis in chromokinesin Kid-depleted (B) vs. control (C) cells. Depletion of Kid inhibits formation of the central clear zone. In contrast, chromosomes in control cells are excluded from the center of the spindle during early prometaphase (C; 02:30 – 07:00). Notice that to generate consistent perspective, both sequences are illustrated by maximal-intensity projections that are perpendicular (left part of each frame) and parallel (right part) to the spindle axis during metaphase.