Figure 4.

Thiol-reactive natural products are cytotoxic to glioma cell lines. Heat maps of glioma cell survival in the presence of thiol-reactive natural products and analogs. LN428 cells have wild-type PTEN and a p53 V173M/R282W mutation. LN827 cells have an Exon 3 splice acceptor mutation of PTEN and a p53 mutation. U87 cells have an Exon 3 splice acceptor mutation of PTEN and a wild-type p53. BT70 cells have a G44V mutation in PTEN and R273C mutation in p53. Cells were treated with the indicated concentrations of the compounds and viability was measured using resazurin 48 h later (in triplicate).