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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Cytotherapy. 2011 Nov;13(10):1164–1171. doi: 10.3109/14653249.2011.620748

Figure 1. Schematic representation of ex vivo expansion of gene-modified cells in a nonhuman primate model.

Figure 1

Bone marrow, peripheral blood, or cord blood hematopoietic stem cells (HSCs) are removed from the monkey for ex vivo manipulation. Cells are gene-modified in vitro and expanded. Prior to infusion, a sample of the cells is tested to determine efficiency of gene correction and safety of the integration site profile. If cells pass this quality-control checkpoint, they are transplanted back into the non-myeloablated monkey.